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Bernard W. Dempsey, S. In a centralized economy, currency is issued by a central bank at a rate that is supposed to match the growth of the amount of goods that are exchanged so that these goods can be traded with stable prices. The monetary base is controlled by a central bank.

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Power rankings: Ohio State makes big move Matt Norlander 9 min read. Title contenders outside the top 10 David Cobb 5 min read. Kentucky falls to Arkansas after controversial foul call Kyle Boone 2 min read. Duke drops below. UNC players apologize after video shows maskless party Kyle Boone 2 min read.

Gonzaga's perfect record includes double-digit victories over Virginia, Iowa and Kansas. The Zags have won their 10 West Coast Conference games by an average of The Bears have won 15 of their 17 games by double-digits. Michigan is in the first two quadrants with double-digit wins over Minnesota, Wisconsin and Purdue.

The Wolverines' lone loss came at Minnesota. Ohio St. Ohio State is in its past nine games with wins over Illinois, Wisconsin and Iowa. The Buckeyes lead the nation with nine Quadrant 1 victories. Illinois is in the first two quadrants after Saturday's win over Wisconsin. The Illini's four-game winning streak consists of four Quadrant 1 victories. Villanova is in its past 11 games with wins over Texas and Seton Hall.

The Wildcats are in the first two quadrants with zero additional losses. Houston is in its past 10 games with eight double-digit wins in that stretch. The Cougars are in the first two quadrants with one additional loss at East Carolina. Missouri is in the first two quadrants with zero additional losses after Saturday's win over Alabama. The Tigers will take a three-game winning streak into Wednesday's game at Ole Miss. The Crimson Tide's only loss outside of the first two quadrants is a December loss to Western Kentucky.

West Virginia improved to in the first two quadrants via Tuesday's double-digit win at Texas Tech. All five of the Mountaineers' losses qualify as Quadrant 1 defeats. Oklahoma is in its past seven games with the lone loss in that stretch coming at Texas Tech. All five of the Sooners' losses qualify as Quadrant 1 defeats. Texas snapped its three-game losing streak Tuesday at Kansas State. The Longhorns are in the first two quadrants with all five losses qualifying as Quadrant 1 defeats.

The Cavaliers are in the first two quadrants with zero additional losses. Florida St. Florida State's five-game winning streak was snapped Saturday at Georgia Tech. The Seminoles are in the first two quadrants with one additional loss to UCF. Virginia Tech is in its past four games after Saturday's win at Miami. The Hokies are in the first two quadrants with zero additional losses. The Trojans are in the first two quadrants with zero additional losses. Tennessee improved to in the first two quadrants with Saturday's win at Kentucky.

All four of the Vols' losses qualify as Quadrant 1 defeats. Wisconsin is in its past five games after Saturday's loss at Illinois. We report the application of single-molecule-based sequencing technology for high-throughput profiling of genes in E-, M-BCSCs and bulk tumor cells in two PDX models of triple negative breast cancer. A compendium of long non-coding RNAs transcriptional fingerprint in multiple myeloma. Multiple myeloma MM is a malignant proliferation of bone marrow plasma cells PCs characterized by highly heterogeneous genetic background and clinical course, and whose pathogenesis remains largely unknown.

Long ncRNAs lncRNAs are a large class of non-protein-coding RNA, involved in many physiological cellular and genomic processes as well as in carcinogenesis, cancer metastasis and invasion. Although still in its infancy, the knowledge of the role of lncRNAs in MM is progressively expanding. Besides studies on selected candidates, lncRNAs expression at genome-wide transcriptome level is confined to microarray technologies, thus investigating a limited collection of transcripts.

Herein, we assessed the lncRNAs expression profiling by RNA-sequencing in a cohort of 30 MM patients, aimed at defining a comprehensive catalogue of lncRNAs specifically associated with the main MM molecular subgroups and genetic alterations. In addition, we identified a list of lncRNAs, with potential relevance in MM, co-expressed and in close proximity to genes that might undergo a cis-regulatory relationship.

The bromodomain and extra-terminal domain BET proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 BRD4 than BRD2, and the BET protein association to histone H4-hyperacetylated chromatin is not understood at the genome-wide level.

This finding supports a model in which recruitment of BET proteins via histone H4 hyperacetylation is predominant over hyperacetylation of histone H4 by BET protein-associated acetyltransferases. In addition, we found a remarkable number of BRD2-bound genes, including MYC and its downstream target genes, were transcriptionally upregulated upon JQ1 treatment. Using BRD2-enriched sites and transcriptional activity analysis, we identified candidate transcription factors potentially involved in the JQ1 response in BRD2-dependent and independent manner.

The steroid co-activator protein SRC-1 plays an important role in endocrine therapy resistant breast cancer. Its expression is associated with large high grade tumours, HER2 positivity, disease recurrence and resistance to endocrine therapy. SRC-1's role in affecting the transcriptome of the breast cancer endocrine resistant setting is uncovered through this RNA-seq analysis of LY2 cells grown with or without the presence of SRC LncRNAs have emerged as key regulator of biological process involved in the development and progression of bladder cancer.

Bladder cancer is one of the most common genitourinary malignancies worldwide, with approximately , new cases and , deaths annually in the world. Our results indicate that the differential expressed lncRNAs in both MIBC tissues and LN-positive tissues associated in a variety of biological functions, such as metastasis. An integrative network biology analysis identifies miRp as the determinant and a prognosis biomarker of the mesenchymal subtype ovarian cancer.

Recently, several research groups have identified the mesenchymal subtype of serous OvCa on the basis of transcriptome data and its potential correlation with poor prognosis. We set out to define the regulatory mechanisms underlying the distinct gene expression profiles of serous OvCa using a network-based approach involving multiple molecular modalities such as gene expression and microRNA miR expression. Our study demonstrated that the mirp presented as the most powerful determinant of mesenchymal subtype-specific gene expression, tuning the majority of genes differentially expressed in the poor prognosis subtype, including genes associated with the epithelial—mesenchymal transition EMT program.

Consequent functional experiments illustrate that miRp inhibition promoted EMT process, in vitro cell migration and invasion, and in vivo cancer metastasis. Purpose: Tamoxifen is the most commonly used antiestrogen drug for breast cancer treatment, however, acquired resistance is a considerable challenge in clinic.

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The defense allowed Still, N. State is allowed Offensively they're fine, rolling up As a result the 'over' is for N. State to date. The Cavaliers rolled to a win over Duke in the opener on Sept. The Hoos hung tough with No.

Like N. State, the Cavaliers haven't had an 'under' result so far, allowing UVA also has an impressive plus-4 turnover margin so far. UVA has cashed in each of their past four at home, while going an impressive ATS in the past 24 against winning teams. The home team has connected in seven of the past nine meetings in this series. The Blue Devils made a lot of friends last week with a field goal in the final seconds, covering for those who bet them early in the week.

While Duke has failed to win in four games so far this season, they showed some signs of life against the Hokies, posting a season-high in points Of course, they also tied a season-worst with 38 points allowed for a second straight game. The Orange stunned Georgia Tech last week as 7. Now, they find themselves as home 'dogs yet again. After managing just 16 total points in their first two games, both on the road, they erupted for 37 points in their first game under the dome.

Despite the win and cover, they're still just ATS in the past nine at home against teams with a losing road record, and ATS in the previous four following a straight up win. The Panthers will be looking to bounce back after a stunning one-point loss at home against N.

State last week, their first straight-up loss of the season. Despite the fact the Panthers allowed 29 point last week, they're still yielding just The Wolfpack did put a dent in Pitt's scoring average allowing, but they're still 11th overal with just The Panthers also have an impressive plus-4 turnover rating.

The Eagles are also looking to bounce back after suffering their first setback of the season. The Eagles easily covered a QB Phil Jurkovec has looked like the real deal, passing for yards, although he has just two passing touchdowns through three games. The 'under' has connected in all three games for Boston College so far, allowing just Offensive coordinator Rhett Lashlee has installed the spread offense for the first time in school history, and it's looking like a winning recipe so far.

The Canes are averaging The defense isn't quite like 'The U in the 80's', but they have allowed just The Tigers are off to another great start, although they are ATS. They have been favored by 27 or more points in each of their games, and they have taken their foot off the gas in the second half while hardly getting a test.

The Hurricanes are likely to provide their first real adversity of the season, although it's uncertain how long it will last. Clemson is averaging If the Tigers wish to make the playoffs and make another run for a national title, they need signature wins, and this could be their first of the season.

The score looks impressive, but they didn't really start pulling away from the Gamecocks until well into the second half, and JSU was actually winning for a little bit. FSU is averaging just They need to get better offensively, and they need to get better in a hurry. Notre Dame hasn't played since Sept. I like NC State here to cover and also win. Two teams that are near the bottom of the ACC.

These are two teams with two really glaring issues. Syracuse has no offensive line, and Duke gives up the ball too much. Could easily see the Blue Devils defensive line man handling Syracuse, but I think the Orange have a little more flash in them and Andre Cisco and company will rattle Chase Brice.

Going again with the underdog, Syracuse to cover and win at home. Miami has been the story of the season so far. D'Eriq King and the Hurricanes offense has been electric, 12 in the country in yards, and 7 in points. Clemson on the other hand is still the juggernaut in the ACC, and no one has come close to knocking them off their perch.

This is their real first test of the season. The Seminoles finally got their first win of the season last week, having to come back to beat Jacksonville St. I don't think FSU really has much of a chance in this game, but I could see them covering on a backdoor cover with something late in the game. I'll get into my rational tomorrow in my official prediction post, but if you want to gamble throw your money on the Eagles.

Think they not only cover this spread, but win outright. You can follow us for future coverage by clicking "Follow" on the top righthand corner of the page. Facebook- BostonCollegeSI. Home Football.